TSC2/Tuberin Rabbit polyclonal Antibody IgG

SKU: BA110686-100µl
$279.00Price

Fig1: Immunocytochemical staining of SH-SY-5Y cells using anti-Tuberin rabbit polyclonal antibody.

Fig2:  Immunocytochemical staining of PANC-1 cells using anti-Tuberin rabbit polyclonal antibody.

Fig3:  Immunohistochemical analysis of paraffin- embedded human pancreas tissue using anti-Tuberin rabbit polyclonal antibody.

Bon Opus Cat. #BA110686
Size
  • Host Species; Species Reactivity

    Rabbit; Human, Mouse
  • Immunogen

    Peptide
  • Application Summary

    ICC, IHC, FC
  • Purification; Formulation

    Peptide affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
  • ALTnames

    Tuberin,Tuberous sclerosis 2 protein
  • Background

    Tuberous sclerosis complex (TSC) is an autosomal dominant genetic disorder characterized by mental retardation and the widespread development of distinctive tumors termed hamartomas. Two different genetic loci have been linked to TSC; one of these loci, the tuberous sclerosis-2 gene (TSC2), encodes a protein called tuberin and the other loci, tuberous sclerosis-1 gene (TSC1), encodes a protein called hamartin. Tuberin and hamartin interact with each other forming a cystoplasmic complex. Hamartin interacts with the ezrin-radixin-moesin (ERM) family of actin-binding proteins and inhibition of hamartin activity results in loss of cell adhesion. Hamartin is present in most adult tissues with strong expression in brain, heart, and kidney.(R1510-2)

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