Transglutaminase 2 Recombinant Rabbit monoclonal Antibody IgG

SKU: BA112412-100µl

Fig1: Western blot analysis of Transglutaminase 2 on mouse placenta (1) and lung tissue lysates using anti-Transglutaminase 2 antibody at 1/500 dilution.

Fig2: Western blot analysis of Transglutaminase 2 on HUVEC cell lysates using anti-Transglutaminase 2 antibody at 1/500 dilution.

Fig3: Immunohistochemical analysis of paraffin-embedded human placenta tissue using anti-Transglutaminase 2 antibody. Counter stained with hematoxylin.

Bon Opus Cat. #BA112412
  • Host Species; Species Reactivity

    Rabbit; Human, Mouse
  • Immunogen

    Recombinant protein
  • Application Summary

  • Purification; Formulation

    ProA affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
  • ALTnames

    Protein-glutamine gamma-glutamyltransferase 2, Tissue transglutaminase, Transglutaminase C, Transglutaminase H, Transglutaminase-2
  • Background

    Terminally differentiating mammalian epidermal cells acquire an insoluble, 10 to 20 nm thick protein deposit on the intracellular surface of the plasma membrane known as the cross-linked cell envelope (CE). The CE is a component of the epidermis that is generated through formation of disulfide bonds and g-glutamyl-lysine isodipeptide bonds, which are formed by the action of transglutaminases (TGases). TGases are intercellularly localizing, Ca2+-dependent enzymes that catalyze the formation of isopeptide bonds by transferring an amine on to glutaminyl residues, thereby cross-linking glutamine residues and lysine residues in substrate proteins. TGases influence numerous biological processes, including blood coagulation, epidermal differentiation, seminal fluid coagulation, fertilization, cell differentiation and apoptosis. Human keratinocyte transglutaminase (TGase1) is a membrane associated, 817 amino acid protein. Human tissue transglutaminase (TGase2) is an endothelial cell specific, 687 amino acid protein.(ET1706-35)

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