TRAF6 Rabbit polyclonal Antibody IgG
Fig1: Western blot analysis on cell lysates using anti-TRAF6 rabbit polyclonal antibodies.
Fig2: ICC staining TRAF6 in Hela cells (green). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Fig3: Western blot analysis of TRAF6 on hybrid fish (crucian-carp) heart tissue lysate using anti-TRAF6 antibody at 1/500 dilution.
Host Species; Species ReactivityRabbit; Human, Mouse, Rat, Zebrafish
Application SummaryICC, IHC
Purification; FormulationPeptide affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
ALTnamesTNF receptor-associated factor 6,E3 ubiquitin-protein ligase TRAF6,Interleukin-1 signal transducer,RING finger protein 85
BackgroundTRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein mediates the signaling not only from the members of the TNF receptor superfamily, but also from the members of the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/TRANCE/RANKL and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines.(R1311-2)