Tet1 Rabbit polyclonal Antibody IgG
Fig1: Immunocytochemical staining of SH-SY-5Y cells using anti-TET1 rabbit polyclonal antibody.
Fig2: Immunohistochemical analysis of paraffin- embedded mouse brain tissue using anti-TET1 rabbit polyclonal antibody.
Fig3: Flow cytometric analysis of SH-SY-5Y cells with TET1 antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated Goat anti rabbit IgG was used as the secondary antibody.
Host Species; Species ReactivityRabbit; Human, Mouse, Rat
ImmunogenSynthetic Peptide (KLH-coupled) within human TET1 820-900 aa.
Application SummaryIHC, FC, ICC
Purification; FormulationPeptide affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
ALTnamesMethylcytosine dioxygenase TET1,CXXC-type zinc finger protein 6,Ten-eleven translocation 1 gene protein homolog
BackgroundTET1 (tet oncogene 1), also known as LCX or CXXC6, is a 2,136 amino acid protein that localizes to the nucleus and contains one CXXC-type zinc finger. Expressed in adult ovary, thymus and skeletal muscle and also present in fetal lung, heart and brain, TET1 is thought to play a role in the development of fetal organs and may also be involvement in the pathoegenesis and metastasis of acute myeloid leukemia (AML). The gene encoding TET1 maps to human chromosome 10, which houses over 1,200 genes and comprises nearly 4.5% of the human genome. Defects in some of the genes that map to chromosome 10 are associated with Charcot-Marie Tooth disease, Jackson-Weiss syndrome, Usher syndrome, nonsyndromatic deafness, Wolman’s syndrome, Cowden syndrome, multiple endocrine neoplasia type 2 and porphyria.(R1510-17)