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TdT Rabbit polyclonal Antibody IgG

SKU: BA110646-100µl
$279.00Price

Fig1: Western blot analysis on Jurkat using anti-TdT polyclonal antibody.

 

 

Bon Opus Cat. #BA110646
Size
  • Host Species; Species Reactivity

    Rabbit; Human
  • Immunogen

    This antibody is produced by immunizing rabbits with a synthetic Peptide (KLH-coupled) corresponding to near C-terminal residues of human TdT.
  • Application Summary

    WB
  • Purification; Formulation

    Immunogen affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
  • ALTnames

    DNA nucleotidylexotransferase,Terminal addition enzyme,Terminal deoxynucleotidyltransferase
  • Background

    Terminal deoxynucleotidyltransferase (TdT) is a DNA polymerase expressed in immature lymphocytes of the thymus and bone marrow, as well as certain leukemic cells. The nuclear enzyme TdT plays a critical role in generating immune receptor diversity. During rearrangement of Ig and TCR V region genes, TdT catalyzes the addition of N nucleotides without a DNA template to V-D and D-J junctions in both Ig and TCR as well as the V-J junctions in the TCR (1–3). During the fetal and newborn period, TdT activity is absent, resulting in an N region-deficient Ag receptor repertoire significantly lacking in the diversity observed in the junctional regions of Igs and TCRs of adult animals(0807-4)