TCL1A Mouse monoclonal Antibody IgG1
Bon Opus Cat. #BA112756
Host Species; Species ReactivityMouse; Human
Application SummaryWB, FC
Purification; FormulationProA affinity purified; 1*TBS (pH7.4), 1%BSA, Preservative: 0.05% Sodium Azide.; Liquid form.
ALTnamesRap1 GTPase-activating protein 1
BackgroundT-cell Leukemia/Lymphoma Protein 1A (TCL-1A), also known as p14TCL1 is a product of the TCL1 gene that is involved in T-cell prolymphocytic leukemia (T-PLL). T-PLL is a rare form of mature T-cell leukemia, which is consistently associated with chromosomal rearrangements characterized by the juxtaposition of the TCRA locus on chromosome 14q11 and the TCL1A gene on 14q32.1. TCL-1A is a member of a unique family of beta barrel proteins that bind small hydrophobic ligands and function in cell regulation. TCL-1A is an all-beta protein containing an eight-stranded antiparallel beta barrel which consists of two four-stranded beta-meander motifs. The two motifs are related by a twofold axis and connected by a long loop. TCL-1A forms a tight crystallographic dimer. TCL-1A is expressed in pre-B cells, in immature thymocytes, at low levels in activated T cells, and in the cytoplasm.(EM1706-59)