TAK1 Recombinant Rabbit monoclonal Antibody IgG
Fig1: Western blot analysis of TAK1 on human placenta tissue lysate using anti-TAK1 antibody at 1/1,000 dilution.
Fig2: ICC staining TAK1 in A431 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Fig3: ICC staining TAK1 in N2A cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Host Species; Species ReactivityRabbit; Human, Mouse
Application SummaryWB, ICC/IF, IHC, FC
Purification; FormulationProA affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
ALTnamesMitogen-activated protein kinase kinase kinase 7, Transforming growth factor-beta-activated kinase 1
BackgroundSeveral serine / threonine protein kinases have been implicated as intermediates in signal transduction pathways. These include ERK / MAP kinases, ribosomal S6 kinase (Rsk) and Raf-1. Raf-1 is a protein with intrinsic kinase activity towards serine / threonine residues and Which is expressed expression in many human types and cell lines. Raf-1 activation is dependent on the small molecular weight GTPase Ras, but the means by which this activation is poorly understood. Two proteins put put involved in this process are Ksr-1 and Taks. Ksr-1 (kinase sup-pressor of Ras) is a novel Raf-related protein kinase whose function is required for Ras signal transduction. Whether or not in a parallel pathway is not yet known. Tak1 (TGFβ-activated kinase) has been shown to participate in the activation of the MAP kinase family in response to TGFβ stimulation.(ET1705-14)