SUZ12 Rabbit polyclonal Antibody IgG
Fig1: Western blot analysis on cell lysates using anti-SUZ12 rabbit polyclonal antibody.
Host Species; Species ReactivityRabbit; Human, Mouse
Purification; FormulationImmunogen affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
ALTnamesPolycomb protein SUZ12,Chromatin precipitated E2F target 9 protein,Joined to JAZF1 protein,Suppressor of zeste 12 protein homolog
BackgroundPolycomb protein SUZ12 is a nuclear protein belonging to the VEFS (VRN2-EMF2-FIS2-SUZ12) family. It is overexpressed in breast and colon cancer, expressed at low levels in quiescent cells. Expression rises at the G1/S phase transition. A chromosomal aberration involving SUZ12 may be a cause of endometrial stromal tumors. The translocation generates the JAZF1-SUZ12 oncogene consisting of the N-terminus part of JAZF1 and the C-terminus part of SUZ12. It is frequently found in all cases of endometrial stromal tumors, except in endometrial stromal sarcomas, where it is rarer.(R1110-2)