SUN1 Recombinant Rabbit monoclonal Antibody IgG
Fig1: Western blot analysis of SUN1 on rat kidney tissue lysate using anti-SUN1 antibody at 1/2,000 dilution.
Fig2: ICC staining SUN1 in A431 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Fig3: Immunohistochemical analysis of paraffin-embedded human breast tissue using anti-SUN1 antibody. Counter stained with hematoxylin.
Host Species; Species ReactivityRabbit; Human, Rat
ImmunogenRecombinant protein corresponding to C-terminal human SUN1.
Purification; FormulationProA affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
ALTnamesSUN domain-containing protein 1, Protein unc-84 homolog A, Sad1/unc-84 protein-like 1
BackgroundUNC84A (UNC84 homolog A), also known as SUN1, is a multi-pass nuclear membrane protein that is involved in nuclear anchoring and migration. Highly expressed in heart, brain and testis, UNC84A functions as an A-type Lamin-binding protein that forms a link between the inner and outer nuclear envelope membranes. This link acts as a structural bridge between the nuclear interior and the Actin cytoskeleton and is essential for proper localization of nuclear envelope proteins. Additionally, UNC84A may be involved in telomere attachment and in normal testis development. UNC84A contains one UNC84 (SUN) domain and exists as four isoforms due to alternative splicing events.(ET7108-91)