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STAT1 Recombinant Rabbit monoclonal Antibody IgG

SKU: BA111441-100µl
$279.00Price

Fig1: Western blot analysis of STAT1 on different lysates using anti-STAT1 antibody at 1/1,000 dilution.

Positive control:   

Lane 1: 293             

Lane 2: NIH/3T3

Fig2: Flow cytometric analysis of MCF-7 cells with STAT1 antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody

 

Bon Opus Cat. #BA111441
Size
  • Host Species; Species Reactivity

    Rabbit; Human, Mouse
  • Immunogen

    Recombinant protein
  • Application Summary

    WB, IP, FC
  • Purification; Formulation

    ProA affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
  • ALTnames

    Signal transducer and activator of transcription 1-alpha/beta, Transcription factor ISGF-3 components p91/p84
  • Background

    Membrane receptor signaling by various ligands, including interferons and growth hormones such as EGF, induces activation of JAK kinases which then leads to tyrosine phosphorylation of the various Stat transcription factors. Stat1 and Stat2 are induced by IFN-α and form a heterodimer which is part of the ISGF3 transcription factor complex. Although early reports indicate Stat3 activation by EGF and IL-6, it has been shown that Stat3β appears to be activated by both while Stat3α is activated by EGF, but not by IL-6. Highest expression of Stat4 is seen in testis and myeloid cells. IL-12 has been identified as an activator of Stat4. Stat5 has been shown to be activated by Prolactin and by IL-3. Stat6 is involved in IL-4 activated signaling pathways.(ET1606-39)