SRC1 Recombinant Rabbit monoclonal Antibody IgG
Fig1: Western blot analysis of SRC1 on K562 cell lysate using anti- SRC1 antibody at 1/2,000 dilution.
Fig2: Immunohistochemical analysis of paraffin-embedded human lung cancer tissue using anti-SRC1 antibody. Counter stained with hematoxylin.
Fig3: Immunohistochemical analysis of paraffin-embedded human thyroid gland tissue using anti-SRC1 antibody. Counter stained with hematoxylin.
Host Species; Species ReactivityRabbit; Human
Purification; FormulationProA affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
ALTnamesNuclear receptor coactivator 1, Class E basic helix-loop-helix protein 74, Protein Hin-2 RIP160, Renal carcinoma antigen NY-REN-52, Steroid receptor coactivator 1
BackgroundNuclear receptors for steroids, thyroid hormones and retinoic acids are ligand-dependent transcription factors that activate transcription through specific DNA binding sites in their target genes. Several related transcriptional coactivators and corepressors have been described that work in concert with the steroid receptor family to either induce or repress transcription from hormone-responsive elements. This family includes GRIP1 (for GR interacting protein 1, also designated NCoA-2 or Tif2); SRC-1 (for steroid receptor coactivator-1, also designated NCoA-1); RAC3 (also designated AIB1, for amplified in breast cancer, or ACTR), which displays elevated expression in estrogen receptor positive ovarian and breast cancers; and p/CIP (for p300/CBP/Co-Integrator Protein), which is required for the transcriptional activation of p300/CBP-dependent transcription factors(ET7107-44)