SOCS2 Recombinant Rabbit monoclonal Antibody IgG
Fig1: Western blot analysis of SOCS2 on different lysates using anti-SOCS2 antibody at 1/1,000 dilution.
Lane 1: Human placenta
Lane 2: SH-SY-5Y
Fig2: ICC staining SOCS2 in LOVO cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Fig3: ICC staining SOCS2 in PC-3M cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Host Species; Species ReactivityRabbit; Human
ImmunogenRecombinant protein within human SOCS2 1-150aa.
Purification; FormulationProA affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
ALTnamesSuppressor of cytokine signaling 2, Cytokine-inducible SH2 protein 2, STAT-induced STAT inhibitor 2
BackgroundSOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.(ET7108-40)