Smad2 Rabbit polyclonal Antibody IgG
Fig1: Immunocytochemical staining of SW480 cells using anti-Smad2 rabbit polyclonal antibody.
Fig2: Immunocytochemical staining of SK-BR-3 cells using anti-Smad2 rabbit polyclonal antibody.
Fig3: Immunocytochemical staining of HepG2 cells using anti-Smad2 rabbit polyclonal antibody.
Host Species; Species ReactivityRabbit; Human, Mouse, Rat
Application SummaryICC, IHC
Purification; FormulationPeptide affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
ALTnamesMothers against decapentaplegic homolog 2, JV18-1, Mad-related protein 2, SMAD family member 2
BackgroundSmad proteins, the mammalian homologs of the Drosophila mothers against decapentaplegic (Mad), have been implicated as downstream effectors of TGF∫/BMP signaling. Smad1 (also designated Madr1 or JV4-1) and Smad5 are effectors of BMP-2 and BMP-4 function, while Smad2 (also designated Madr2 or JV18-1) and Smad3 are involved in TGF∫ and Activin-mediated growth modulation. Smad4 (also designated DPC4) has been shown to mediate all of the above activities through interaction with various Smad family members. Smad6 and Smad7 regulate the response to Activin/TGF∫ signaling by interfering with TGF∫-mediated phosphorylation of other Smad proteins.(R1511-29)