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SIRT3 Rabbit polyclonal Antibody IgG

SKU: BA110612-100µl
$279.00Price

Fig1: Western blot analysis on different lysates using anti-SIRT3 rabbit polyclonal antibody. Positive control: 

Lane 1: A172       

Lane 2: Mouse liver 

Lane 3: NIH/3T3    

Lane 4: Mouse kidney 

Lane 5: F9

Fig2:  Immunocytochemical staining of MCF-7 cells using anti-SIRT3 rabbit polyclonal antibody.

Fig3:  Immunocytochemical staining of HepG2 cells using anti-SIRT3 rabbit polyclonal antibody.

Bon Opus Cat. #BA110612
Size
  • Host Species; Species Reactivity

    Rabbit; Human, Mouse
  • Immunogen

    Peptide
  • Application Summary

    WB, ICC, IHC, FC
  • Purification; Formulation

    Peptide affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
  • ALTnames

    NAD-dependent protein deacetylase sirtuin-3, mitochondrial,Regulatory protein SIR2 homolog 3,SIR2-like protein 3
  • Background

    The Silent Information Regulator (SIR2) family of genes are highly conserved from prokaryotes to eukaryotes and are involved in diverse processes, including transcriptional regulation, cell cycle progression, DNA-damage repair and aging. In S. cerevisiae, Sir2p deacetylates histones in an NAD-dependent manner, which regulates silencing at the telomeric, rDNA and silent mating-type loci. Sir2p is the founding member of a large family, designated sirtuins, which contain a conserved catalytic domain. The human homologues, which include SIRT1-7, are divided into four main branches: SIRT1-3 are class I, SIRT4 is class II, SIRT5 is class III and SIRT6-7 are class IV. SIRT3 is a NAD-dependent deacetylase that contains one deacetylase sirtuin-type domain. The SIRT3 protein is widely expressed and localizes to the mitochondira where it is processed by mitochondrial processing peptidase (MPP) to yield a final product. This processing is most-likely necessary for its enzymatic activity.(R1511-3)