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SHC1 Mouse monoclonal Antibody IgG1

SKU: BA112737-100µl

Fig1: Western blot analysis of SHC1 on human SHC1 recombinant protein using anti-SHC1 antibody at 1/1,000 dilution.

Fig2: Western blot analysis of SHC1 on HEK293 (1) and SHC1-hIgGFc transfected HEK293 (2) cell lysate using anti-SHC1 antibody at 1/1,000 dilution.

Fig3: Western blot analysis of SHC1 on NIH/3T3 cell lysate using anti-SHC1 antibody at 1/1,000 dilution.

Bon Opus Cat. #BA112737
  • Host Species; Species Reactivity

    Mouse; Human, Mouse
  • Immunogen

    Recombinant protein
  • Application Summary

    WB, ICC, FC
  • Purification; Formulation

    ProA affinity purified; 1*TBS (pH7.4), 1%BSA, Preservative: 0.05% Sodium Azide.; Liquid form.
  • ALTnames

    Interferon-inducible protein AIM2, Absent in melanoma 2
  • Background

    Growth factor triggering of protein tyrosine kinase receptors induces signals that cascade to the nucleus activating mitogenic, as well as other, responses. Critical components of this process include adapter proteins such as Shc and IRS-1 that lack detectable catalytic activity. These are immediate substrates of receptor tyrosine kinase activity and serve to physically link activated receptors to downstream signaling components. Whereas Shc has been implicated in signaling by diverse receptor families, IRS-1 serves primarily as the major insulin receptor substrate (4-7). Shc also participates in insulin signaling by linking the insulin receptor to Ras by forming complexes with the adapter protein GRB2 and Sos independently of IRS-1. A protein immunologically related to IRS-1, originally designated 4PS and now known as IRS-2, was shown to become highly tyrosine phosphorylated in response to IL-4 or IGF-1 in cells lacking IRS-1. An additional member of this family of signaling intermediates, Shb, is a SH2-containing protein with characteristic proline-rich domains.(EM1706-40)