SCAI Mouse monoclonal Antibody IgM
Fig1: Western blot analysis of SCAI on Recombinant protein using anti-SCAI antibody at 1/1,000 dilution.
Fig2: ICC staining SCAI in SHG-44 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Fig3: ICC staining SCAI in SH-SY-5Y cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Host Species; Species ReactivityMouse; Human
Application SummaryWB, ICC, IHC
Purification; FormulationProA affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
ALTnamesProtein SCAI, Suppressor of cancer cell invasion protein
BackgroundProtein SCAI, also known as Suppressor of cancer cell invasion protein, and encoded by the gene name SCAI, is a tumor suppressor that suppresses MKL1-induced SRF transcriptional activity. It is a regulator of cell migration and appears to be involved in the RhoA (ras homolog gene family, member A)-Dia1 (diaphanous homolog 1) signal transduction pathway. SCAI localizes in the nucleus, where it binds and inhibits the myocardin-related transcription factor MAL by forming a ternary complex with serum response factor (SRF).(M1004-5)