ROR2 Mouse monoclonal Antibody IgG1
Fig1: Western blot analysis of ROR2 on human ROR2 recombinant protein using anti-ROR2 antibody at 1/1,000 dilution.
Fig2: Western blot analysis of ROR2 on HEK293 (1) and ROR2-hIgGFc transfected HEK293 (2) cell lysate using anti-ROR2 antibody at 1/1,000 dilution.
Fig3: Flow cytometric analysis of Hela cells with ROR2 antibody at 1/100 dilution (green) compared with an unlabelled control (cells without incubation with primary antibody; red).
Host Species; Species ReactivityMouse; Human
Application SummaryWB, FC
Purification; FormulationProA affinity purified; 1*TBS (pH7.4), 1%BSA, Preservative: 0.05% Sodium Azide.; Liquid form.
BackgroundROR2 (receptor tyrosine kinase-like orphan receptor 2), also known as neurotrophic tyrosine kinase receptor-related 2 (NTRKR2), is a single pass transmembrane tyrosine-protein kinase receptor. It contains a cytoplasmic tyrosine kinase domain, distally located serine-threonine-rich domains, an extracellular immunoglobulin-like domain, a cysteine-rich domain and a kringle domain. ROR2 is important for skeletal and endocrine development and is required for cartilage and growth plate development. It promotes the differentiation of osteoblasts and plays an important role in the early formation of chondrocytes. ROR2 sequesters and associates with Dlxin-1 affecting the transcriptional function of Msx-2. ROR2 also interacts with canoncial Wnt1 and Wnt3, regulating their signaling pathways. Defects in ROR2 can result in the autosomal dominant skeletal disorder, brachydactyly type B1 or the autosomal recessive skeletal disorder, Robinow syndrome.(EM1706-8)