ROCK1 Recombinant Rabbit monoclonal Antibody IgG

SKU: BA111579-100µl

Fig1: Western blot analysis of ROCK1 on different lysates using anti-ROCK1 antibody at 1/1,000 dilution.

Positive control:   

Lane 1: A431           

Lane 2: NIH/3T3

Fig2: Immunohistochemical analysis of paraffin-embedded mouse thyroid tissue using anti-ROCK1 antibody. Counter stained with hematoxylin.

Fig3: Immunohistochemical analysis of paraffin-embedded mouse heart tissue using anti-ROCK1 antibody. Counter stained with hematoxylin.

Bon Opus Cat. #BA111579
  • Host Species; Species Reactivity

    Rabbit; Human, Mouse, Rat
  • Immunogen

    Recombinant protein
  • Application Summary

  • Purification; Formulation

    ProA affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
  • ALTnames

    Rho-associated protein kinase 1, Renal carcinoma antigen NY-REN-35, Rho-associated, coiled-coil-containing protein kinase 1, Rho-associated, coiled-coil-containing protein kinase I, p160 ROCK-1
  • Background

    Rho, the Ras-related small GTPase, is responsible for the regulation of Actin-based cytoskeletal structures including stress fibers, focal adhesions and the contractile ring apparatus. Rho proteins function as molecular switches that are able to turn cytokinesis on and off. Although little is known about signaling downstream of Rho, a host of putative Rho effector proteins have been described, including rhophilin, Rhotekin, citron and the serine/threonine kinase, protein kinase N. Two additional Rho-activated serine/threonine kinases have been described, designated Rock-1 and Rock-2 (also referred to as Roka, for Rho-associated coil-containing protein kinase). Rock-1 and Rock-2 share a structural similarity with myotonic dystrophy kinase.(ET1609-53)

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