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ROCK1 Rabbit polyclonal Antibody IgG

SKU: BA110593-100µl

Fig1: Western blot analysis of ROCK1 on different cell lysates using anti-ROCK1 antibody at 1/1000 dilution.

Positive control:   

Lane 1: NIH/3T3           

Lane 2: Jurkat 

Lane 3: Hela

Fig2: Immunohistochemical analysis of paraffin-embedded human colon cancer tissue using anti-ROCK1 antibody. Counter stained with hematoxylin.


Bon Opus Cat. #BA110593
  • Host Species; Species Reactivity

    Rabbit; Human, Mouse
  • Immunogen

  • Application Summary

    WB, IHC
  • Purification; Formulation

    Peptide affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
  • ALTnames

    Rho-associated protein kinase 1,Renal carcinoma antigen NY-REN-35,Rho-associated, coiled-coil-containing protein kinase 1,Rho-associated, coiled-coil-containing protein kinase I,p160 ROCK-1
  • Background

    ROCK1 is a protein serine/threonine kinase also known as rho-associated, coiled-coil-containing protein kinase 1. ROCK1 has a ubiquitous tissue distribution, but subcellularly it is thought to colocalize with the centrosomes. This is consistent with its function as a key modulator of cell motility, tumor cell invasion, and actin cytoskeleton organization. ROCK1 has a diverse range of functions in the body. It is a key regulator of actin-myosin contraction, stability, and cell polarity. These contribute to many progresses such as regulation of morphology, gene transcription, proliferation, differentiation, apoptosis and oncogenic transformation. Other functions involve smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility. These functions are activated by phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, PFN1 and PPP1R12A.(ER40122)