ROCK1 Rabbit polyclonal Antibody IgG
Fig1: Western blot analysis of ROCK1 on different cell lysates using anti-ROCK1 antibody at 1/1000 dilution.
Lane 1: NIH/3T3
Lane 2: Jurkat
Lane 3: Hela
Fig2: Immunohistochemical analysis of paraffin-embedded human colon cancer tissue using anti-ROCK1 antibody. Counter stained with hematoxylin.
Host Species; Species ReactivityRabbit; Human, Mouse
Application SummaryWB, IHC
Purification; FormulationPeptide affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
ALTnamesRho-associated protein kinase 1,Renal carcinoma antigen NY-REN-35,Rho-associated, coiled-coil-containing protein kinase 1,Rho-associated, coiled-coil-containing protein kinase I,p160 ROCK-1
BackgroundROCK1 is a protein serine/threonine kinase also known as rho-associated, coiled-coil-containing protein kinase 1. ROCK1 has a ubiquitous tissue distribution, but subcellularly it is thought to colocalize with the centrosomes. This is consistent with its function as a key modulator of cell motility, tumor cell invasion, and actin cytoskeleton organization. ROCK1 has a diverse range of functions in the body. It is a key regulator of actin-myosin contraction, stability, and cell polarity. These contribute to many progresses such as regulation of morphology, gene transcription, proliferation, differentiation, apoptosis and oncogenic transformation. Other functions involve smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility. These functions are activated by phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, PFN1 and PPP1R12A.(ER40122)