Recombinant Mouse PDGFR α/PDGFRA/CD140a (C-6His)
Recombinant Mouse PDGF receptor alpha is produced by our Mammalian expression system and the target gene encoding Leu25-Glu524 is expressed with a 6His tag at the C-terminus. Bon Opus Cat. #CP12
BackgroundPlatelet-derived growth factor receptors (PDGFR) are cell surface tyrosine kinase receptors for members of the platelet-derived growth factor (PDGF) family. The PDGF family consists of PDGF-A, -B, -C and -D, which form either homo- or heterodimers (PDGF-AA, -AB, -BB, -CC, -DD). The four PDGFs are inactive in their monomeric forms. PDGFs bind to the protein tyrosine kinase receptors PDGF receptor-α and -β. These two receptor isoforms dimerize upon binding the PDGF dimer, leading to three possible receptor combinations, namely -αα, -ββ and -αβ. PDGFRα and PDGFRβ are members of the class III RTK family. Inappropriate PDGFRα and PDGFRβ signaling has been linked to a number of proliferative disorders.
FormulationLyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
ALTnamesPlatelet-derived growth factor receptor alpha, PDGF-R-alpha, Alpha platelet-derived growth factor receptor, Alpha-type platelet-derived growth factor receptor, CD140a, Pdgfra