Recombinant Human Plexin Domain-Containing Protein 1/PLXDC1 (C-6His)
Recombinant Human Plexin Domain-Containing Protein 1 is produced by our Mammalian expression system and the target gene encoding Leu19-Thr426 is expressed with a 6His tag at the C-terminus. Bon Opus Cat. #C529
BackgroundPlexin Domain-Containing Protein 1 (PLXDC1) is a single-pass type I membrane protein that belongs to the plexin family. Secreted PLXDC1 is localized predominantly at the tight junctions of vascular endothelial cells and to a lesser extent at the luminal surface of vascular endothelial cells. PLXDC1 is expressed in fibrovascular membrane with increased expression in individuals with proliferative diabetic retinopathy. It can detect in endothelial cells from colorectal cancer, and in endothelial cells from primary cancers of the lung, liver, pancreas, breast and brain. PLXDC1 interacts with NID1 and may also interact with CTTN. It plays a important role in endothelial cell capillary morphogenesis, the proliferation and maintenance of neovascular endothelial cells in the formation of fibrovascular membranes (FVMs).
FormulationLyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, 5% Threhalose, pH 7.2.
ALTnamesPlexin Domain-Containing Protein 1, Tumor Endothelial Marker 3, Tumor Endothelial Marker 7, PLXDC1, TEM3, TEM7