BackgroundTumor necrosis factor receptor superfamily member 25 (TNFRSF25) contains 1 death domain and 4 TNFR-Cys repeats. TNFRSF25 is a cell surface receptor of the tumor necrosis factor receptor superfamily which mediates apoptotic signalling and differentiation, activated by a monogamous ligand, known as TL1A (TNFSF15), which is rapidly upregulated in antigen presenting cells and some endothelial cells following Toll-Like Receptor or Fc receptor activation. This receptor has been shown to signal both through the TRADD adaptor molecule to stimulate NF-kappa B activity or through the FADD adaptor molecule to stimulate caspase activation and regulate cell apoptosis. It may play a role in regulating lymphocyte homeostasis.
FormulationLyophilized from a 0.2 μm filtered solution of PBS,pH7.4.
ALTnamesTumor necrosis factor receptor superfamily member 25,APO3, DDR3, DR3, TNFRSF12, WSL, WSL1,TNFRSF25,Protein WSL-1,LARD,Protein WSL,Lymphocyte-associated receptor of death,Death receptor 3,Apoptosis-mediating receptor TRAMP,Apoptosis-inducing receptor AIR,Apoptosis-mediating receptor DR3,Apo-3