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Recombinant Human Apurinic-Apyrimidinic Endonuclease 1/APE
Recombinant Human Apurinic-Apyrimidinic Endonuclease 1 is produced by our E.coli expression system and the target gene encoding Pro2-Leu318 is expressed. Bon Opus Cat. #C101

Recombinant Human Apurinic-Apyrimidinic Endonuclease 1/APE

SKU: C101-10ug
$110.00Price
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Phone: 800-943-6396 ext#1

Email: orders@bonopusbio.com

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Shipping Information

$48 Standard Overnight flat rate for products shipped in room temperature within the United States.

 

Additional $27 Ice Packs shipment fee is required for liquid proteins.

 

Please contact us to order for  international shipments.

Endotoxin
Less than 0.1 ng/ug (1 EU/ug) as determined by LAL test.
Accession Number
AAH02338.1
Species
Human
Expression System
E.coli
Target Sequence
Pro2-Leu318
Tag
tag free
Formulation
Supplied as a 0.2 um filtered solution of 10mM HEPES, 100mM KCl, 50% Glycerol, pH 7.4.
Packaging
Dry ice/Polar packs
Background
Apurinic-Apyrimidinic Endonuclease 1 (APE1) is required for efficient DNA base excision repair. When the DNA glycosylase remove the damaged bases, APE1 cleaves the AP site to allow resynthesis and ligation to complete repair. APE1 stimulates the DNA binding activity of many transcription factors, which participate in cancer promotion and progression. APE1 regulates the redox state of multiple transcription factors, such as c-Jun, c-Fos, NF-kB, p53. APEN is also involved in calcium-dependent down-regulation of PTH expression.
Purity
Greater than 95% as determined by reducing SDS-PAGE.
DNA-(Apurinic or Apyrimidinic Site) Lyase; APEX Nuclease; APEN; Apurinic-Apyrimidinic Endonuclease 1; AP Endonuclease 1; APE-1REF-1; Redox Factor-1; APEX1; APE; APE1; APEX; APX; HAP1; REF1
Alternative Names
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Citation
NA
Activity
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