Recombinant 2019-nCoV S Protein RBD (N501Y, C-Fc)

Recombinant 2019-nCoV S Protein RBD (N501Y, C-Fc)

SKU: DRA121-50ug
$190.00Price
Recombinant 2019-nCoV S-RBD is produced by our Mammalian expression system and the target gene encoding Arg319-Ser541(N501Y) is expressed with a Fc tag at the C-terminus.
Size
  • Accession Number

    QHD43416.1
  • Expression

    Human 293 Cells
  • Packaging

    Dry ice/ice pack
  • Formulation

    Supplied as a 0.2 um filtered solution of PBS, pH7.4
  • Background

    The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
  • ALTnames

    2019-nCov RBD Protein; 2019-nCoV Spike RBD Protein; 2019-nCoV S Protein RBD; 2019-nCoV S-RBD
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