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RAN Mouse monoclonal Antibody IgG1

SKU: BA112715-100µl
$279.00Price

Fig1: Western blot analysis of RAN on  human RAN  recombinant protein using anti-RAN antibody at 1/1,000 dilution.

Fig2: Western blot analysis of RAN on HEK293 (1) and RAN-hIgGFc transfected HEK293 (2) cell lysate using anti-RAN antibody at 1/1,000 dilution.

Fig3: Western blot analysis of RAN on different cell lysate using anti-RAN antibody at 1/1,000 dilution.

Positive control: Line1: Hela     Line2: NIH/3T3     Line3: A431  Line4: C6       Line5: Jurkat      Line6: Hela  Line7: COS7     Line8: Jurkat

Bon Opus Cat. #BA112715
Size
  • Host Species; Species Reactivity

    Mouse; Human, Mouse, Monkey, Rat
  • Immunogen

    Recombinant protein
  • Application Summary

    WB, IHC, ICC, FC
  • Purification; Formulation

    ProA affinity purified; 1*TBS (pH7.4), 1%BSA, Preservative: 0.05% Sodium Azide.; Liquid form.
  • ALTnames

    Probable ATP-dependent RNA helicase DDX20, Component of gems 3, DEAD box protein 20, DEAD box protein DP 103, Gemin-3
  • Background

    The small Ras-related protein Ran, also called TC4, is a nuclear localized GTPase implicated in a diverse array of cellular processes including DNA replication, entry into and exit from mitosis and the transport of RNA and proteins through the nuclear pore complex. Like Ras, active Ran GTP and inactive Ran GDP levels are tightly regulated by guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs). The abundant GEF, RCC1 (regulator of chromosome condensation 1), increases the rate at which Ran exchanges GDP for GTP. Ran GAP1 opposes the effects of RCC1 by increasing the rate at which Ran hydrolyzes GTP to GDP. A protein designated Ran BP1 has no intrinsic GAP activity, and functions as a GEF inhibitor deactivating RCC1 and thereby indirectly increasing the ratio of Ran GDP to Ran GTP. The Ran BP2 protein has been proposed as the Ran GTP docking site at the periphery of the nuclear pore complex.(EM1706-18)