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RAD23A Mouse monoclonal Antibody IgG2b

SKU: BA112722-100µl
$279.00Price

Fig1: Western blot analysis of RAD23A on  human RAD23A recombinant protein using anti-RAD23A antibody at 1/1,000 dilution.

Fig2: Western blot analysis of RAD23A on  HEK293 (1) and RAD23A)-hIgGFc transfected HEK293 (2) cell lysate using anti-RAD23A antibody at 1/1,000 dilution.

Fig3: Immunohistochemical analysis of paraffin-embedded human  bladder cancer tissue using anti-RAD23A antibody. Counter stained with hematoxylin.

Bon Opus Cat. #BA112722
Size
  • Host Species; Species Reactivity

    Mouse; Human
  • Immunogen

    Recombinant protein
  • Application Summary

    WB, IHC, FC
  • Purification; Formulation

    ProA affinity purified; 1*TBS (pH7.4), 1%BSA, Preservative: 0.05% Sodium Azide.; Liquid form.
  • ALTnames

    Protein Wnt-3a
  • Background

    Mammalian cells express two Rad23 (genome repair protein) homologs, Rad23A (also designated HR23A) and Rad23B (also designated HR23B). In typical cells, mouse Rad23B is approximately ten times more abundant than mouse Rad23A. Endogenous XPC (xeroderma pigmentosum C protein) located in wildtype mouse embryonic fibroblasts is relatively stable; its steady-state level and stability appear to be significantly reduced by a targeted interruption of the mouse Rad23B gene, but not by that of mouse Rad23A. Loss of both mouse Rad23 genes causes a strong further reduction of the XPC protein level. The RAD23 genes (RAD23A and RAD23B), which encode the human Rad23 proteins, are crucial for excision-repair of UV-damaged DNA. RAD23 genes resemble the other DNA repair genes, RAD2, RAD6, RAD7, RAD18 and RAD54, all of which also exhibit increased transcription in response to DNA damage and during meiosis. Rad23 is a nuclear protein containing an ubiquitin-like domain required for biological functions. The protein, which is highly conserved, is involved in nucleotide excision repair (NER) that associates with the proteasome via its N-terminus. The C-terminal ubiquitin-associated domain of Rad23 is evolutionarily conserved from yeast to humans. Rad23 may also act as a regulator for the activity of the 26S Proteasome.(EM1706-25)