PTP1B Mouse monoclonal Antibody IgG1

SKU: BA110734-100µl

Fig1: Western blot analysis on different cell lysates using anti-PTP1B Mouse mAb. Positive control: 

Lane 1: A431        

Lane 2: Hela 

Lane 3: HepG2      

Lane 4: A549

Fig2:  Immunocytochemical staining of Hela cells using anti-PTP1B Mouse mAb.

Fig3:  Immunocytochemical staining of A549 cells using anti-PTP1B Mouse mAb.

Bon Opus Cat. #BA110734
  • Host Species; Species Reactivity

    Mouse; Human, Mouse, Rat
  • Immunogen

    Recombinant protein
  • Application Summary

    WB, ICC, FC
  • Purification; Formulation

    ProA affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
  • ALTnames

    Tyrosine-protein phosphatase non-receptor type 1, Protein-tyrosine phosphatase 1B
  • Background

    The phosphorylation of proteins at tyrosine residues has long been recognized as an important regulatory component of signal transduction. This is a reversible process, involving both enzymes that phosphorylate proteins on tyrosine residues as well as a rapidly expanding family of protein tyrosine phosphatases. These latter enzymes bear little resemblance to either the protein serine and protein threonine phosphatases or to the acid and alkaline phosphatases. In most tissues, the major PTPase is a vanadate- and molybdate-sensitive protein. On the basis of sequence analysis, PTP1B (PTPase 1B) expressed in human placenta exhibits similarities both with the common leukocyte antigen (CD45) and with LAR, a homolog of the neural adhesion molecule (NCAM). PTP1B is synthesized as a 435 amino acid precursor protein which is cleaved to generate the active 321 amino acid enzyme.(M1511-7)

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