PTBP1 Rabbit polyclonal Antibody IgG
Fig1: Western blot analysis on cell lysates using anti- PTBP1 rabbit polyclonal antibodies.
Fig2: ICC staining PTBP1 in Hela cells (green). Cells were fixed in paraformaldehyde.
Fig3: Immunohistochemical analysis of paraffin-embedded mouse testis tissue using anti- PTBP1 rabbit polyclonal antibody.
Host Species; Species ReactivityRabbit; Human, Mouse, Rat
Application SummaryWB, ICC, IHC
Purification; FormulationPeptide affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
ALTnamesPolypyrimidine tract-binding protein 1,57 kDa RNA-binding protein PPTB-1,Heterogeneous nuclear ribonucleoprotein I
BackgroundPolypyrimidine tract-binding protein 1 is a protein that in humans is encoded by the PTBP1 gene. It plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. PTBP1 activates exon skipping of its own pre-mRNA during muscle cell differentiation. It binds to the polypyrimidine tract of introns and may promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. PTBP1 may promote the binding of U2 snRNP to pre-mRNA. It cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10.(R1403-2)