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PTBP1 Rabbit polyclonal Antibody IgG

SKU: BA110573-100µl
$279.00Price

Fig1: Western blot analysis on cell lysates using anti- PTBP1 rabbit polyclonal antibodies.

Fig2: ICC staining PTBP1 in Hela cells (green). Cells were fixed in paraformaldehyde.

Fig3: Immunohistochemical analysis of paraffin-embedded mouse testis tissue using anti- PTBP1 rabbit polyclonal antibody.

Bon Opus Cat. #BA110573
Size
  • Host Species; Species Reactivity

    Rabbit; Human, Mouse, Rat
  • Immunogen

    Peptide
  • Application Summary

    WB, ICC, IHC
  • Purification; Formulation

    Peptide affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
  • ALTnames

    Polypyrimidine tract-binding protein 1,57 kDa RNA-binding protein PPTB-1,Heterogeneous nuclear ribonucleoprotein I
  • Background

    Polypyrimidine tract-binding protein 1 is a protein that in humans is encoded by the PTBP1 gene. It plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. PTBP1 activates exon skipping of its own pre-mRNA during muscle cell differentiation. It binds to the polypyrimidine tract of introns and may promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. PTBP1 may promote the binding of U2 snRNP to pre-mRNA. It cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10.(R1403-2)