PSD95 Rabbit polyclonal Antibody IgG
Fig1: Western blot analysis on different cell lysates using anti- PSD95 rabbit polyclonal antibodies.
Fig2: Immunohistochemical analysis of paraffin-embedded rat brain tissue using anti- PSD95 rabbit polyclonal antibody.
Fig3: Immunohistochemical analysis of paraffin-embedded mouse brain tissue using anti- PSD95 rabbit polyclonal antibody.
Host Species; Species ReactivityRabbit; Human, Mouse, Rat
Application SummaryWB, IHC, FC
Purification; FormulationPeptide affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
ALTnamesDisks large homolog 4,Postsynaptic density protein 95,Synapse-associated protein 90
BackgroundPSD-95 is a member of the membrane-associated guanylate kinase(MAGUK) family. With PSD-93 it is recruited into the same NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins.PSD-95 is the best studied member of the MAGUK-family of PDZ domain-containing proteins. Like all MAGUK-family proteins, its basic structure includes three PDZ domains, an SH3 domain, and a guanylate kinase-like domain (GK) connected by disordered linker regions. It is almost exclusively located in the post synaptic density ofneurons,and is involved in anchoring synaptic proteins. Its direct and indirect binding partners include neuroligin,NMDA receptors,AMPA receptors, and potassium channels.It plays an important role in synaptic plasticity and the stabilization of synaptic changes during long-term potentiation.(R1508-4)