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Prohibitin (Mitochondrial Marker) Rabbit polyclonal Antibody IgG

SKU: BA110567-100µl
$279.00Price

Fig1: Western blot analysis on different cell lysates using anti-Prohibitin rabbit polyclonal antibody. Positive control: 

Lane 1: F9       

Lane 2: Jurkat 

Lane 3: Mouse kidney  

Lane 4: PC-12

Fig2:  Immunocytochemical staining of Hela cells using anti-Prohibitin rabbit polyclonal antibody.

Fig3:  Immunocytochemical staining of HepG2 cells using anti-Prohibitin rabbit polyclonal antibody.

Bon Opus Cat. #BA110567
Size
  • Host Species; Species Reactivity

    Rabbit; Human, Mouse, Rat
  • Immunogen

    Peptide
  • Application Summary

    WB, ICC, IHC, FC
  • Purification; Formulation

    Peptide affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
  • ALTnames

    Prohibitin
  • Background

    Prohibitin is an evolutionarily conserved protein that has antiproliferative activity. The gene encoding human prohibitin maps to chromosome 17q21 and is ubiquitously expressed. Prohibitin is a post-synthetically modified protein that is localized in the inner membrane of mitochondria, where it regulates the cell cycle by blocking the transition between the G1 and S phases, and on the plasma membrane of B cells, where it mediates B cell maturation. Prohibitin mRNA and protein levels are high in G1, decline during the S phase, rise again in G2 and decline in M phase, which suggests that prohibitin controls the cell cycle by using both transcriptional and posttranslational mechanisms. Prohibitin is also a potential tumor suppressor protein that binds to retinoblastoma (Rb) and subsequently inhibits the activity of E2F family members in response to specific signaling cascades. Prohibitin 2 is a repressor of estrogen receptor activity, and is required for somatic and germline differentiation in the larval gonad during embryonic development. Mutations in the Prohibitin genes are correlated with breast cancer development and/or progressionin more than 80% of the cell lines analyzed.(R1510-30)