PP2A (alpha+beta) Rabbit polyclonal Antibody IgG
Fig1: Western blot analysis on different cell lysates using anti-PP2A(alpha+beta) rabbit polyclonal antibody. Positive control:
Lane 1: A431
Lane 2: HepG2
Lane 3: F9
Lane 4: PC-12
Fig2: Immunocytochemical staining of Hela cells using anti-PP2A(alpha+beta) rabbit polyclonal antibody.
Host Species; Species ReactivityRabbit; Human, Mouse, Rat
Application SummaryWB, ICC, IHC, FC
Purification; FormulationPeptide affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
ALTnamesSerine/threonine-protein phosphatase 2A catalytic subunit alpha isoform,Replication protein C
BackgroundIn eukaryotes, the phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions, including division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the protein phosphatases. In general, the protein phosphatase (PP) holoenzyme is a trimeric complex composed of a regulatory subunit, a variable subunit, and a catalytic subunit. Four major families of protein phosphatase catalytic subunits have been identified, designated PP1, PP2A, PP2B (calcineurin) and PP2C. An additional protein phosphatase catalytic subunit, PPX (also known as PP4) is a putative member of a novel PP family. The PP2A family comprises subfamily members PP2Aβ and PP2A∫. The PP2A catalytic subunit associates with a variety of regulatory subunits. Regulatory subunits include PP2A-A-α and -A-β, PP2A-B-α and -B-β, PP2A-C-α and -C-β, PP2A-B56-α and -B56-β.(R1510-31)