PLA2G12A Mouse monoclonal Antibody IgG1
Fig1: Western blot analysis of PLA2G12A on human PLA2G12A recombinant protein using anti-PLA2G12A antibody at 1/1,000 dilution.
Fig2: Western blot analysis of PLA2G12A on HEK293 (1) and PLA2G12A-hIgGFc transfected HEK293 (2) cell lysate using anti-PLA2G12A antibody at 1/1,000 dilution.
Fig3: Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-PLA2G12A antibody. Counter stained with hematoxylin.
Host Species; Species ReactivityMouse; Human
Application SummaryWB, IHC, FC
Purification; FormulationProA affinity purified; 1*TBS (pH7.4), 1%BSA, Preservative: 0.05% Sodium Azide.; Liquid form.
BackgroundSecreted phospholipases A2 (sPLA2s) form a large family of structurally related enzymes, which are widespread in nature. Snake venoms have been known for decades to contain a tremendous molecular diversity of sPLA2s, which can exert a myriad of toxic and pharmacological effects. Secreted phospholipase A2 enzymes liberate arachidonic acid from phospholipids for production of eicosanoids and exert a variety of physiologic and pathologic effects. Group XII sPLA2s, such as group XIIA sPLA2, have relatively low specific activity and are structurally and functionally distinct from other sPLA2s. Group XIIA sPLA2, also known as GXII, ROSSY, PLA2G12 or PLA2G12A, is a 189 amino acid secreted protein that localizes to the cytoplasm. Belonging to the phospholipase A2 family, group XIIA sPLA2 is abundantly expressed in heart, skeletal muscle, kidney, liver and pancreas(EM1706-96)