PI3-kinase p85 subunit alpha Mouse monoclonal Antibody IgG1

SKU: BA110553-100µl
$279.00Price

Fig1: Western blot analysis on different cell lysates using anti-PI3-kinase p85 subunit alpha Mouse mAb. Positive control: 

Lane 1: U-937      

Lane 2: Raji

Fig2:  Immunocytochemical staining of Hela cells using anti-PI3-kinase p85 subunit alpha Mouse mAb.

Fig3:  Immunocytochemical staining of MCF-7 cells using anti-PI3-kinase p85 subunit alpha Mouse mAb.

Bon Opus Cat. #BA110553
Size
  • Host Species; Species Reactivity

    Mouse; Human, Mouse, Rat
  • Immunogen

    Recombinant protein
  • Application Summary

    WB, ICC, IHC, FC
  • Purification; Formulation

    ProA affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
  • ALTnames

    Phosphatidylinositol 3-kinase regulatory subunit alpha,Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha
  • Background

    Phosphatidylinositol 3-kinase (PI 3-kinase) is composed of (p85) and (p110) subunits. p85 lacks PI 3-kinase activity and acts as an adapter, coupling p110 to activated protein tyrosine kinase. Two forms of p85 have been described (p85α and p85β), each possessing one SH3 and two SH2 domains. Various p110 isoforms have been identified. p110α and p110β interact with p85α, and p110α has also been shown to interact with p85β in vitro. p110δ expression is restricted to white blood cells. It has been shown to bind p85α and γ, but it apparently does not phosphorylate these subunits. p110δ seems to have the capacity to autophosphorylate. p110γ does not interact with the p85 subunits. It has been shown to be activated by α and βγ heterotrimeric G proteins.(M1510-2)

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