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Phospho-Synapsin Ⅰ (S9) Recombinant Rabbit monoclonal Antibody IgG

SKU: BA111726-100µl
$279.00Price

Fig1: Immunohistochemical analysis of paraffin-embedded rat brain tissue using anti- phospho-Synapsin Ⅰ (S9) antibody. Counter stained with hematoxylin.

Fig2: Immunohistochemical analysis of paraffin-embedded mouse brain tissue using anti- phospho-Synapsin Ⅰ (S9) antibody. Counter stained with hematoxylin.

 

Bon Opus Cat. #BA111726
Size
  • Host Species; Species Reactivity

    Rabbit; Human, Mouse, Rat
  • Immunogen

    Synthetic phospho-Peptide corresponding to residues surrounding Ser9 of human SynapsinⅠ
  • Application Summary

    WB, IHC
  • Purification; Formulation

    ProA affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
  • ALTnames

    Synapsin-1, Brain protein 4.1, Synapsin I
  • Background

    Synapsins are synaptic vesicle-associated phosphoproteins that regulate synaptic vesicle exocytosis and may be involved in synaptogenesis. Evidence suggests that Synapsin I, Synapsin II and Synapsin IIIa are ATP-binding proteins that are regulated by Ca2+ and calmodulin binding. Ca2+ has been shown to stimulate ATP binding to Synapsin I, to have no effect on Synapsin II and to inhibit Synapsin III. Synapsin I and Synapsin II both undergo alternative splicing to produce two forms of each protein, Synapsin la and lb and Synapsin IIa and IIb, respectively. Synapsin III gives rise to at least three isoforms: Synapsin IIIa, IIIb and IIIc. Synapsin III plays unique roles both in early axon outgrowth and in the regulation of synaptic vesicle trafficking. In cultured mouse hippocampal neurons, Synapsin III is expressed early during development, with levels peaking seven days after plating and declining thereafter. Synapsin III is highly concentrated in growth cones.(ET1611-26)