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Phospho-p53 (S392) Recombinant Rabbit monoclonal Antibody IgG

SKU: BA111434-100µl

Fig1: Western blot analysis of Phospho-p53(S392) on different lysates using anti-Phospho-p53(S392) antibody at 1/1,000 dilution.

Positive control: 

  Lane 1: 293 

  Lane 2: F9

Fig2: Immunohistochemical analysis of paraffin-embedded human gastric carcinoma tissue using anti-Phospho-p53(S392) antibody. Counter stained with hematoxylin.

Fig3: Immunohistochemical analysis of paraffin-embedded mouse prostate tissue using anti-Phospho-p53(S392) antibody. Counter stained with hematoxylin.

Bon Opus Cat. #BA111434
  • Host Species; Species Reactivity

    Rabbit; Human, Mouse
  • Immunogen

    Synthetic phospho-Peptide corresponding to residues surrounding Ser392 of human p53.
  • Application Summary

    WB, IHC, IP
  • Purification; Formulation

    ProA affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
  • ALTnames

    Epidermal growth factor receptor, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1
  • Background

    p53 is a DNA-binding, oligomerization domain- and transcription activation domain-containing tumor suppressor that upregulates growth arrest and apoptosis-related genes in response to stress signals, thereby influencing programmed cell death, cell differentiation and cell cycle control mechanisms. p53 localizes to the nucleus yet can be chaperoned to the cytoplasm by the negative regulator MDM2, an E3 ubiquitin ligase that is upregulated in the presence of active p53, where MDM2 polyubiquitinates p53 for proteasome targeting. p53 can assemble into tetramers in the absence of DNA, fluctuates between latent and active (DNA-binding) conformations, and is differentially activated through posttranslational modifications including phosphorylation and acetylation. Mutations in the DNA-binding domain (DBD) (amino acids 110-286) of p53 can compromise energetically favorable association with cis elements and are implicated in several human cancers. Phosphorylation of p53 at residue Thr 155 is mediated by the COP9 signalosome (CSN) and targets p53 to ubiquitin-26S Proteasome-dependent degradation.(ET1606-24)