Phospho-GATA3 (S308) Recombinant Rabbit monoclonal Antibody IgG
Fig1: Western blot analysis of Phospho-GATA3(S308) on human skin lysates using anti-Phospho-GATA3(S308) antibody at 1/1,000 dilution.
Fig2: Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using anti-Phospho-GATA3(S308) antibody. Counter stained with hematoxylin.
Host Species; Species ReactivityRabbit; Human
ImmunogenSynthetic phospho-Peptide corresponding to residues surrounding Ser308 of human GATA3.
Application SummaryWB, IHC, IP
Purification; FormulationProA affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
ALTnamesTrans-acting T-cell-specific transcription factor GATA-3, GATA-binding factor 3
BackgroundGATA-3 antibody (GATA binding protein 3) is a member of the GATA family of transcription factors. GATA-3 appears to control a set of genes involved in the differentiation and proliferation of breast cancer. The expression of GATA-3 has a strong association with estrogen receptor-alpha expression in breast cancer and evidence exists that GATA-3 may be used to predict response to hormonal therapy of breast cancer patients. GATA-3 has also been shown to be a novel marker for bladder cancer. In one study, GATA-3 stained 67% of 308 urothelial carcinomas but no prostate or renal carcinomas.(ET1609-17)