Phospho-FOXO3a (S253) Recombinant Rabbit monoclonal Antibody IgG

SKU: BA111575-100µl
$279.00Price

Fig1: Western blot analysis of Phospho-FOXO3a(S253) on different lysates using anti-Phospho-FOXO3a(S253) antibody at 1/1,000 dilution.

Positive control: 

  Lane 1: Hela 

  Lane 2: PC12

Fig2: Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-Phospho-FOXO3a(S253) antibody. Counter stained with hematoxylin.

Fig3: Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using anti-Phospho-FOXO3a(S253) antibody. Counter stained with hematoxylin.

Bon Opus Cat. #BA111575
Size
  • Host Species; Species Reactivity

    Rabbit; Human, Mouse, Rat
  • Immunogen

    Synthetic phospho-Peptide corresponding to residues surrounding Ser253 of human FOXO3a.
  • Application Summary

    WB, IHC
  • Purification; Formulation

    ProA affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
  • ALTnames

    Forkhead box protein O3, AF6q21 protein, Forkhead in rhabdomyosarcoma-like 1
  • Background

    FKHRL1 (for forkhead in rhabdomyosarcoma) is a member of the FKHR subfamily of forkhead transcription factors. Transcriptional activation of FKHR proteins is regulated by the serine/threonine kinase Akt1, which phosphorylates FKHRL1 at threonine-32 and serine-253. Phosphorylation by Akt1 negatively regulates FKHRL1 by promoting its export from the nucleus. Phosphorylated FKHRL1 associates with 14-3-3 proteins and this complex is retained in the cytoplasm. Growth factor withdrawal stimulates FKHRL1 dephosphorylation and nuclear translocation, leading to FKHR-induced gene-specific transcriptional activation. Within the nucleus, dephospho-rylated FKHRL1 triggers apoptosis by inducing the expression of genes that are critical for cell death.(ET1609-49)

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