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PHF10 Rabbit polyclonal Antibody IgG

SKU: BA110995-100µl
$279.00Price

Fig1: Western blot analysis of PHF10 on Hela cell lysate using anti-PHF10 antibody at 1/1,000 dilution.

 

Fig2: Immunohistochemical analysis of paraffin-embedded rat testis tissue using anti-PHF10 antibody. Counter stained with hematoxylin.

Fig3: Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-PHF10 antibody. Counter stained with hematoxylin.

Bon Opus Cat. #BA110995
Size
  • Host Species; Species Reactivity

    Rabbit; Human, Mouse, Rat
  • Immunogen

    Recombinant protein
  • Application Summary

    WB,IHC
  • Purification; Formulation

    Protein affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
  • ALTnames

    PHD finger protein 10,BRG1-associated factor 45a,XAP135
  • Background

    Involved in transcription activity regulation by chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.(ER1511-14)