PGC1 alpha+beta Recombinant Rabbit monoclonal Antibody IgG
Fig1: Western blot analysis of PGC1 alpha+beta on different lysates using anti-PGC1 alpha+beta antibody at 1/1,000 dilution.
Lane 1: Mouse brain
Lane 2: Mouse heart
Lane 3: Mouse kidney
Host Species; Species ReactivityRabbit; Human, Mouse, Rat
Purification; FormulationProA affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
ALTnamesPeroxisome prolifeRator-activated receptor gamma coactivator 1-beta, PGC-1-related estrogen receptor alpha coactivator, Peroxisome prolifeRator-activated receptor gamma coactivator 1-alpha, Ligand effect modulator 6
BackgroundTranscription factors exert their effects by associating with co-activator or corepressor proteins. The co-activator complexes are thought to be constitutively active, requiring only proper positioning in the genome to initiate transcription. Co-activators include the steroid receptor coactivator (SRC) and CREB binding protein (CBP) families that contain histone acetyltransferase (HAT) activity, which modifies chromatin structure. PPARgamma co-activator-1 (PGC-1) is a transcriptional cofactor of nuclear respiratory factor-1 (NRF-1), PPARbeta, PPARalpha and other nuclear receptors that is induced by exposure to cold temperatures and is involved in regulating thermogenic gene expression, protein uncoupling, and mitochondrial biogenesis. PGC-1 has a low inherent transcriptional activity when it is not bound to a transcription factor. Docking of PGC-1 to PPARgamma stimulates an apparent conformational change that then enables PGC-1 to bind to and assemble into complexes, which include the additional cofactors SRC-1 and CBP/p300, and results in a large increase in transcriptional activity.(ET1702-96)