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PBP Recombinant Rabbit monoclonal Antibody IgG

SKU: BA111618-100µl

Fig1: Western blot analysis of PBP on mouse brain lysates using anti-PBP antibody at 1/1,000 dilution.

Fig2: ICC staining PBP in PC-3M cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Fig3: Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-PBP antibody. Counter stained with hematoxylin.

Bon Opus Cat. #BA111618
  • Host Species; Species Reactivity

    Rabbit; Human, Mouse, Rat, Zebrafish
  • Immunogen

    Recombinant protein
  • Application Summary

  • Purification; Formulation

    ProA affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
  • ALTnames

    Phosphatidylethanolamine-binding protein 1, HCNPpp, Neuropolypeptide h3, Prostatic-binding protein, Raf kinase inhibitor protein, Hippocampal cholinergic neurostimulating peptide
  • Background

    Members of the a-chemokine subfamily of inducible, secreted, pro-inflammatory cytokines contain a similar motif, in which the first two cysteine residues are separated by a single residue (Cys-X-Cys), and are also chemotactic for neutrophils. The platelet basic protein (PBP), a member of the a(lpha)-chemokine family, resides in the a(lpha)-granules of platelets and is released upon their activation. Proteolytic cleavage of the amino terminus of PBP leads to the generation of several peptides, which include mature PBP, connective tissue-activating peptide III (CTAP III, also designated low affinity platelet factor IV (LA-PF4)), b-thromboglobulin (b-TG), and neutrophil-activating peptide 2 (NAP-2). PBP and its N-truncated derivatives mediate inflammation and wound healing. Specifically, NAP-2 activates chemotaxis and degranulation in neutrophils during inflammation. The gene encoding human PBP maps to chromosome 4q12-q13.(ET1610-18)