Pax8 Mouse monoclonal Antibody IgG1
Fig1: Western blot analysis of Pax8 on skov-3 cells lysates using anti-Pax8 antibody at 1/500 dilution.
Fig2: Immunohistochemical analysis of paraffin-embedded human thyroid gland tissue using anti-Pax8 antibody. Counter stained with hematoxylin.
Host Species; Species ReactivityMouse; Human
ImmunogenSynthetic Peptide corresponding to human Pax8 aa 400-450.
Purification; FormulationPeptide affinity purified.; 1*TBS (pH7.4), 0.5%BSA, 50%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
BackgroundThe PAX gene family has an important role in the formation of tissues and organs during embryonic development and maintaining the normal function of some cells after birth. The PAX genes give instructions for making proteins that attach themselves to certain areas of DNA. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. PAX8 releases the hormones important for regulating growth, brain development, and metabolism. Also functions in very early stages of kidney organogenesis, the müllerian system, and the thymus. Additionally, PAX8 is expressed in the renal excretory system, epithelial cells of the endocervix, endometrium, ovary, Fallopian tube, seminal vesicle, epididymis, pancreatic islet cells and lymphoid cells. PAX8 and other transcription factors play a role in binding to DNA and regulating the genes that drive thyroid hormone synthesis (Tg, TPO, Slc5a5 and Tshr). This PAX-8 antibody is intended for qualified laboratories to qualitatively identify by light microscopy the presence of associated antigens in sections of formalinfixed, paraffin-embedded tissue sections using IHC test methods.(EM1701-81)