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PAX6 Recombinant Rabbit monoclonal Antibody IgG

SKU: BA111859-100µl
$279.00Price

Fig1: Western blot analysis of PAX6 on mouse eyes lysates using anti-PAX6 antibody at 1/1,000 dilution.

Fig2: Immunohistochemical analysis of paraffin-embedded rat eyes tissue using anti-PAX6 antibody. Counter stained with hematoxylin.

Fig3: Immunohistochemical analysis of paraffin-embedded mouse eyes tissue using anti-PAX6 antibody. Counter stained with hematoxylin.

Bon Opus Cat. #BA111859
Size
  • Host Species; Species Reactivity

    Rabbit; Human, Mouse, Rat
  • Immunogen

    Recombinant protein
  • Application Summary

    WB, IHC, FC
  • Purification; Formulation

    ProA affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
  • ALTnames

    Paired box protein Pax-6, Aniridia type II protein, Oculorhombin
  • Background

    Pax genes contain paired domains with strong homology to genes in Drosophila which are involved in programming early development. Lesions in the Pax-6 gene account for most cases of aniridia, a congenital malformation of the eye, chiefly characterized by iris hypoplasia, which can cause blindness. Pax-6 is involved in other anterior segment malformations besides aniridia, such as Peters anomaly, a major error in the embryonic development of the eye with corneal clouding with variable iridolenticulocorneal adhesions. The Pax-6 gene encodes a transcriptional regulator that recognizes target genes through its paired-type DNA-binding domain. The paired domain is composed of two distinct DNA-binding subdomains, the amino-terminal subdomain and the carboxy-terminal subdomain, which bind respective consensus DNA sequences. The human Pax-6 gene produces two alternatively spliced isoforms that have the distinct structure of the paired domain.(ET1612-58)