PARP2 Recombinant Rabbit monoclonal Antibody IgG
Fig1: Western blot analysis of PARP2 on SiHa and Raji cell lysates using anti-PARP2 at 1/500 dilution.
Fig2: Flow cytometric analysis of SH-SY-5Y cells with PARP2 antibody at 1/50 dilution (Fuchsia) compared with an unlabelled control (cells without incubation with primary antibody; Yellow). Alexa Fluor 488-conjugated goat anti-rabbit IgG was used as the secondary antibody.
Host Species; Species ReactivityRabbit; Human, Mouse, Rat
ImmunogenRecombinant protein within the C-terminus of human PARP2.
Purification; FormulationProA affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
ALTnamesPoly [ADP-ribose] polymerase 2, ADP-ribosyltransferase diphtheria toxin-like 2, NAD(+) ADP-ribosyltransferase 2, Poly[ADP-ribose] synthase 2
BackgroundInvolved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates serine ADP-ribosylation of target proteins following interaction with HPF1; HPF1 conferring serine specificity.(ET7108-05)