PAI-3 Rabbit polyclonal Antibody IgG
Fig1: Western blot analysis on human liver using anti-PAI3 polyclonal antibody.
Host Species; Species ReactivityRabbit; Human
Application SummaryWB, ICC
Purification; FormulationImmunogen affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
ALTnamesPlasma serine protease inhibitor，Acrosomal serine protease inhibitor，Plasminogen activator inhibitor 3，Protein C inhibitor，Serpin A5
BackgroundPAI-3 also called Protein C inhibitor (PCI) was originally described in plasma as an inhibitor of the anticoagulant serine protease activated protein C. PCI is present not only in plasma, but also in urine and in many other body fluids and secretions. The highest PCI concentrations have been described in seminal plasma (200 μg/ml). The inhibition is regulated by glycosaminoglycans, such as heparin and heparan sulphate, and several polyanions. As well as its roles in the regulation of hemostasis and fertilisation, Protein C Inhibitor is involved in cell inflammation, proliferation, apoptosis, tumor cell migration, invasion, and metastasis.(0812-5)