p70 S6 Kinase beta Rabbit polyclonal Antibody IgG
Fig1: Western blot analysis of p70 S6 Kinase beta on different cell lysates using anti-p70 S6 Kinase beta antibody at 1/500 dilution.
Lane 1: PC12
Lane 2: NIH/3T3
Lane 3: Jurkat
Lane 4: K562
Lane 5: Hela
Fig2: ICC staining p70 S6 Kinase beta in Lovo cells (green). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Fig3: ICC staining p70 S6 Kinase beta in NIH/3T3 cells (green). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Host Species; Species ReactivityRabbit; Human, Mouse, Rat
Application SummaryWB, ICC, IHC, FC
Purification; FormulationPeptide affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
ALTnamesRibosomal protein S6 kinase beta-2,70 kDa ribosomal protein S6 kinase 2,S6 kinase-related kinase，Serine/threonine-protein kinase 14B,p70 ribosomal S6 kinase beta
Backgroundp70 S6 kinase is a mitogen activated Ser/Thr protein kinase that is required for cell growth and G1 cell cycle progression. p70 S6 kinase phosphorylates the S6 protein of the 40S ribosomal subunit and is involved in translational control of 5' oligopyrimidine tract mRNAs. A second isoform, p85 S6 kinase, is derived from the same gene and is identical to p70 S6 kinase except for 23 extra residues at the amino terminus, which encode a nuclear localizing signal. Both isoforms lie on a mitogen activated signaling pathway downstream of phosphoinositide-3 kinase (PI-3K) and the target of rapamycin, FRAP/mTOR, a pathway distinct from the Ras/MAP kinase cascade. Ribosomal protein S6 kinase beta-2 is an enzyme that in humans is encoded by the RPS6KB2 gene. Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation.(ER31205)