P63 Rabbit polyclonal Antibody IgG
Fig1: Western blot analysis on Hela and MCF-7 cell lysates using anti-p63 rabbit polyclonal antibodies.
Fig2: Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using anti- p63 rabbit polyclonal antibody.
Host Species; Species ReactivityRabbit; Human, Mouse, Rat
Application SummaryWB, IHC
Purification; FormulationPeptide affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
ALTnamesTumor protein 63,Chronic ulceRative stomatitis protein,KeRatinocyte transcription factor KET,Transformation-related protein 63,Tumor protein p73-like,p40，p51
BackgroundTumor protein p63 is a member of the p53 family of transcription factors. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. TP63 mutations underlie several malformation syndromes that include cleft lip and/or palate as a hallmark feature. p63 immunostaining has utility for head and neck squamous cell carcinomas, differentiating prostatic adenocarcinoma (the most common type of prostate cancer) and benign prostatic tissue; normal prostatic glands stain with p63 (as they have basal cells), while the malignant glands in prostatic adenocarcinoma (which lacks these cells) do not. P63 is also helpful in distinguishing poorly differentiated squamous cell carcinoma from small cell carcinoma or adenocarcinoma.(R1311-3)