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©2020 by Bon Opus Biosciences, LLC.

P53 Mouse monoclonal Antibody IgG1

SKU: BA110527-100µl
$279.00Price

Fig1: Western blot analysis on 293 cell lysates using anti- p53 mouse mAb.

Fig2: ICC staining p53 in A431 cells (red). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Fig3: Immunohistochemical analysis of paraffin-embedded human liver carcinoma tissue using anti- p53 mouse monoclonal antibody.

Bon Opus Cat. #BA110527
Size
  • Host Species; Species Reactivity

    Mouse; Human, Mouse
  • Immunogen

    Peptide
  • Application Summary

    WB, ICC, IHC
  • Purification; Formulation

    ProG affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
  • ALTnames

    Cellular tumor antigen p53,Antigen NY-CO-13,Phosphoprotein p53,Tumor suppressor p53
  • Background

    Cellular tumor antigen p53 is crucial in multicellular organisms, where it regulates the cell cycle and, thus, functions as a tumor suppressor, preventing cancer. As such, p53 has been described as "the guardian of the genome" because of its role in conserving stability by preventing genome mutation. Activated p53 binds DNA and activates expression of several genes including microRNA miR-34a, WAF1/CIP1 encoding for p21 and hundreds of other down-stream genes. p21 (WAF1) binds to the G1-S/CDK (CDK2) and S/CDK complexes (molecules important for the G1/S transition in the cell cycle) inhibiting their activity. p53 expression can be stimulated by UV light, which also causes DNA damage. In this case, p53 can initiate events leading to tanning.(M1312-2)