Nudel Recombinant Rabbit monoclonal Antibody IgG
Fig1: Western blot analysis of Nudel on rat brain tissue lysate using anti-Nudel antibody at 1/2,000 dilution.
Fig2: Immunohistochemical analysis of paraffin-embedded human liver cancer tissue using anti-Nudel antibody. Counter stained with hematoxylin.
Fig3: Immunohistochemical analysis of paraffin-embedded human small intestine tissue using anti-Nudel antibody. Counter stained with hematoxylin.
Host Species; Species ReactivityRabbit; Human, Mouse, Rat
ImmunogenRecombinant protein corresponding to the N-terminus of human Nudel.
Purification; FormulationProA affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
ALTnamesNuclear distribution protein nudE-like 1, Mitosin-associated protein 1
BackgroundNudE-like protein (Ndel1) is expressed in the testis, brain, heart, hypothalamus, liver, lung, spleen, and stomach, specifically in the interphase centrosome and mitotic spindle. It positively regulates minus-end directed dynein. Evidence suggests that Ndel1 interacts with LIS1 to sustain the function of dynein, thereby impacting microtubule organization, nuclear translocation, and neuronal positioning. Ndel1 is phosphorylated during mitosis and seems to tether dynactin and dynein to the mother centriole for microtubule anchoring. Loss of function of Ndel1 in the developing neocortex impairs neuronal positioning and uncouples the centrosome and nucleus. Ndel1 may also impair mitochondrial transport or function, initiating a cascade of events culminating in psychiatric illness such as lissencephaly and schizophrenia.(ET7108-73)