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Nudel Recombinant Rabbit monoclonal Antibody IgG

SKU: BA112632-100µl

Fig1: Western blot analysis of Nudel on rat brain tissue lysate using anti-Nudel antibody at 1/2,000 dilution.

Fig2: Immunohistochemical analysis of paraffin-embedded human liver cancer tissue using anti-Nudel antibody. Counter stained with hematoxylin.

Fig3: Immunohistochemical analysis of paraffin-embedded human small intestine tissue using anti-Nudel antibody. Counter stained with hematoxylin.

Bon Opus Cat. #BA112632
  • Host Species; Species Reactivity

    Rabbit; Human, Mouse, Rat
  • Immunogen

    Recombinant protein corresponding to the N-terminus of human Nudel.
  • Application Summary

  • Purification; Formulation

    ProA affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
  • ALTnames

    Nuclear distribution protein nudE-like 1, Mitosin-associated protein 1
  • Background

    NudE-like protein (Ndel1) is expressed in the testis, brain, heart, hypothalamus, liver, lung, spleen, and stomach, specifically in the interphase centrosome and mitotic spindle. It positively regulates minus-end directed dynein. Evidence suggests that Ndel1 interacts with LIS1 to sustain the function of dynein, thereby impacting microtubule organization, nuclear translocation, and neuronal positioning. Ndel1 is phosphorylated during mitosis and seems to tether dynactin and dynein to the mother centriole for microtubule anchoring. Loss of function of Ndel1 in the developing neocortex impairs neuronal positioning and uncouples the centrosome and nucleus. Ndel1 may also impair mitochondrial transport or function, initiating a cascade of events culminating in psychiatric illness such as lissencephaly and schizophrenia.(ET7108-73)