Nucleolin Rabbit polyclonal Antibody IgG
Fig1: Western blot analysis on different cell lysates using anti-nucleolin rabbit polyclonal antibodies.
Fig2: ICC staining nucleolin in mouse embryonic stem cells (red). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS and counterstained with DAPI in order to highlight the nucleus (blue).
Host Species; Species ReactivityRabbit; Human, Mouse
Application SummaryWB, ICC
Purification; FormulationImmunogen affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
BackgroundNucleolin is a multi-functional protein that is one of the major components of the nucleoli. It plays an essential role in various steps of ribosome biogenesis including rRNA synthesis, processing of pre-rRNA, pre-ribosomal RNA assembly, and transport of ribosomal proteins out of the nucleus. While the main function of nucleolin is ribosome biogenesis, it plays an important role in various other nuclear activities. Down regulation of nucleolin leads to increased expression of p53, defects in genome duplication, and a delay at prometaphase during mitosis leading to cell cycle arrest.(R1307-2)