Noxa Recombinant Rabbit monoclonal Antibody IgG
Fig1: Immunohistochemical analysis of paraffin-embedded human spleen tissue using anti-Noxa antibody. Counter stained with hematoxylin.
Fig2: Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-Noxa antibody. Counter stained with hematoxylin.
Fig3: Flow cytometric analysis of Jurkat cells with Noxa antibody at 1/100 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black).
Host Species; Species ReactivityRabbit; Human
Application SummaryWB, IHC, FC
Purification; FormulationProA affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
ALTnamesPhorbol-12-myristate-13-acetate-induced protein 1, Immediate-early-response protein APR, Protein Noxa
BackgroundMembers of the Bcl-2 family of proteins interact to regulate programmed cell death (apoptosis) under a broad range of physiological conditions. Bcl-2, Bcl-xL, and several related proteins inhibit apoptosis, whereas other members of the Bcl-2 family, such as Bax and Bak, enhance cell death. NOXA, a pro-apoptotic member of the Bcl-2 family, contains the Bcl-2 homology 3 (BH3) region, but does not contain other BH domains. Murine cells constitutively express NOXA mRNA in small amounts in various organs; X-ray irradiation increases NOXA mRNA and protein expression levels. In human cells, NOXA, alternatively designated PMA-induced protein 1 or APR, displays high expression in the adult T cell leukemia cell line IKD, where it may function as an immediate-early-response gene. The NOXA protein selectively localizes to mitochondria.(ET1704-35)